• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to the cosmetic use of an ulvanated sulfated polysaccharide as a tensor and / or skin smoothing agent. It also relates to a cosmetic treatment method intended to provide a tightening effect and / or smoothing of the skin, and in particular to reduce and / or erase and / or smooth wrinkles, fine lines of the skin and bags under eyes, characterized in that it comprises the application on the skin of a cosmetic composition comprising at least one sulphated polysaccharide of ulvan type.
    公开号:FR3021535A1
    申请号:FR1454794
    申请日:2014-05-27
    公开日:2015-12-04
    发明作者:Anne Potter；Marion Ghibaudo；Yegor Domanov
    申请人:LOreal SA；
    IPC主号:
    专利说明:

    [0001] The present invention relates to the cosmetic treatment of the skin and more particularly of loose skin and skin with wrinkles, fine lines, and bags under the eyes, with a tensioning agent and / or smoothing the skin. During the aging process, it is generally observed an alteration of the structure and cutaneous functions that results in the manifestation of various signs on the skin, very characteristic of this aging. The main clinical signs of skin aging, common to all types of skin, are the appearance of fine lines and deep wrinkles, linked to sagging skin, which increases with age. In addition, there is a disorganization of the "grain" of the skin, the microrelief of the skin being less regular and having an anisotropic character. There is also a loss of firmness and tonicity of the skin which, as for wrinkles and fine lines, is at least partly explained by dermal and epidermal atrophy, as well as a flattening of the dermoepidermal formation; the skin is less thick and flaccid; it is called "relaxed".
    [0002] It is known to treat these signs of aging by using cosmetic or dermatological compositions containing active agents such as α-hydroxy acids, (3-hydroxy-acids and retinoids) These active agents act on wrinkles by eliminating dead cells skin cells and stimulating the process of cell renewal, but these have the disadvantage of being effective for the treatment of wrinkles only after a certain time of application, and there is a constant need for capable of immediately correcting the cutaneous relaxation by tightening effect and thus to provide a smoothing of skin and to attenuate or even eliminate, immediately wrinkles and fine lines.Tensors acting according to the mechanism described above are already known to date for the treatment of loose skin, for example: - tensors of natural origin, such as proteins and hydrolyzates of vegetal proteins staples, especially soy protein; humectant polysaccharides such as carrageenans; certain synthetic polymers. However, the effectiveness of such tensors is limited in time. In particular, it tends to disappear during the day, and the tensor film fractures, especially during face mimicry. What is more, these assets generally have a tensor effect which tends to stiffen the skin, which is uncomfortable for the user. There remains, therefore, a need for active agents capable of immediately correcting slackening of the skin by a tensor effect, while being comfortable.
    [0003] There is also a need for assets capable of effectively perpetuating this immediate effect over time for a period of at least 6 hours, and preferably at least 12 hours. Finally, it is necessary that this immediate and lasting tensor effect allows to obtain skin smoothing properties without generating feelings of discomfort, such as tugging or rigidity, for the user. Unexpectedly, the inventors have discovered that an ulna-type sulphated polysaccharide has a tensor effect on the skin, which makes it possible precisely to attenuate the wrinkles of the skin in an immediate and lasting manner, without creating a stiffening effect. uncomfortable for the user.
    [0004] Thus, the invention relates to the cosmetic use of an ulvanated sulfated polysaccharide as a tensor and / or skin smoothing agent. The use of this agent makes it possible to reduce and / or erase and / or smooth the wrinkles and fine lines of the skin, as well as the bags under the eyes, as well as to reduce the skin microrelief and the roughness of the skin, by effect tensor.
    [0005] Sulphated polysaccharides of the ulvane type are sulphated anionic polysaccharides with rhamnose motif (6-deoxy-hexose of the aldose type), derived from green algae belonging to the order of the ulvals. Ulvans are located at the cell wall of algal cells, and are prepared by extraction in an aqueous medium. The cosmetic use of these polysaccharides as a moisturizing agent of the skin has already been described in document FR 2 982 152. On the other hand, to the knowledge of the inventors, polysaccharides have never been proposed as tensor agents of the skin. In particular, the ulna-type sulphated polysaccharide is extracted, or used in the form of an extract containing it, from one of the following species: Ulva lactuca, Ulva rigida, Ulva armoricana, Ulva rotundata, Ulva obscura, Enteromorpha compressa, Enteromorpha intestinalis and Enteromorpha ramulosa, and their combinations.
    [0006] More particularly, the sulphated polysaccharide of ulvan type is extracted from the species Ulva rotundata, or used in the form of an extract containing it. The invention also relates to a cosmetic treatment method intended to provide a tightening and / or smoothing effect on the skin and in particular to reduce and / or erase and / or smooth out wrinkles, fine lines of the skin and puffiness. under the eyes, characterized in that it comprises the application on said skin of a cosmetic composition comprising at least one sulphated polysaccharide of ulvan type. For the purposes of the invention, the term "tensioning agent and / or skin smoothing" means an active ingredient acting on the skin by stretching and therefore smoothing. This effect is obtained after application and drying of the composition containing it, on the surface of the skin. This type of action has the effect of providing a decrease in the microrelief of the treated skin. As a result, wrinkles and fine lines fade. The ability of an active ingredient to soften or smooth the skin may also be characterized by the experimental protocol as described in Example 2. This makes it possible to evaluate the degree of shrinkage (value of the tensor effect). Observed on a stratum corneum leaf treated with such an active agent. A tensor effect (ET) value greater than or equal to 20%, and preferably greater than or equal to 30%, qualifies a tensor effect. Consequently, a "tensor effect" is to be distinguished from the effect obtained with anti-aging agents that also act on wrinkles, but not immediately, by eliminating dead skin cells, and by stimulating the process of 20 cell renewal. In particular, the invention relates to the cosmetic use of an ulvanated sulfated polysaccharide as a skin tensor, to diminish and / or erase and / or smooth the wrinkles and fine lines of the skin. A wrinkle is a fold of the skin, usually caused by aging of the skin and is a consequence of a chronological and therefore progressive alteration of collagen and elastin. The first wrinkles usually appear around 30 years old. In general, wrinkles are located on the forehead, at the outer contours of the eyes, at the level of the mouth and between the two eyebrows. A wrinkle is a crease on the skin that forms a small wrinkle. Fine lines are less shallow than wrinkles but appear earlier.
    [0007] The invention also relates to the cosmetic use of an ulvanated sulphated polysaccharide as a skin tightening agent, for reducing the cutaneous microrelief of the skin. It can include the smoothing of bags under the eyes. "Cutaneous microrelief reduction" refers both to the reduction in the depth of the microgrooves and to the reduction of their number, some of which are caused to disappear by the action of the tensor effect agent. Although smooth, the skin of the face remains flexible and lends itself to the manifestation of mimicry without generating a feeling of tightness. The invention also relates to the cosmetic use of an ulvarated sulphated polysaccharide as a skin tensing agent to reduce skin roughness. The term "roughness of the skin" refers to the presence of asperities. More specifically, the use of a sulphated polysaccharide of the ulvan type makes it possible, by its tensor effect, to reduce the roughness of the skin, by tending it so that the asperities are smoothed and the skin is less granular. Advantageously, the tensor effect of the skin obtained by using the sulphated polysaccharide of ulvan type is an immediate effect, that is to say occurring within less than two hours, as is shown in Example 2 Advantageously, the tensor effect of the skin obtained by the use of the ulna-type sulphated polysaccharide is a residual effect which persists over time. Example 2 shows in particular that this tensor effect, making it possible to reduce the roughness of the skin, lasts for a period of 18 hours after the topical application of the tensioning agent. Advantageously, the tensor effect of the skin obtained by the use of the sulphated polysaccharide of the ulvan type does not cause discomfort to the user since it does not stiffen the skin as conventionally used tensing agents. It is further noted that an ulna-type sulfated polysaccharide is advantageous for reducing pore visibility. Ulvans As stated above, the sulphated polysaccharides of the ulvan type, for the purposes of the invention, refer to sulphonated anionic polysaccharides with a rhamnose (6-deoxy-hexose-type aldose) pattern conforming to those isolated from green algae belonging to the order of the ulvals. The terms "ulvans" and "Ulvane" in the present invention are used interchangeably for these polysaccharides.
    [0008] Ulvans are water-soluble sulfated anionic polysaccharides that are located at the cell level in the cell wall. Ulvans are particularly extracted from ulvae or enteromorphs. These green algae are part of the phyllum chlorophytes and order ulvals characterized by a thallus tube (enteromorph) or double layer cell (ulva).
    [0009] According to a particular aspect of the invention, the ulna-type sulphated polysaccharide is extracted or used in the form of an extract of ulvae or enteromorphs. These extracts of ulvans can be obtained from numerous ulva species among which mention may be made of Ulva lactuca, Ulva rigida, Ulva armoricana, Ulva rotundata and Ulvaria obscura, as well as several species of enteromorphs such as in particular Enteromorpha compressa, Enteromorpha intestinalis and Enteromorpha ramulosa. According to a particular aspect of the invention, the ulna-type sulphated polysaccharide is extracted or used in the form of an extract of at least one of the following species: Ulva lactuca, Ulva rigida, Ulva armoricana, Ulva rotundata, Ulva obscura, Enteromorpha compressa, Enteromorpha intestinalis and Enteromorpha ramulosa, and combinations thereof, and preferably of the species Ulva rotundata. The ulvans preferably represent from 8 to 29% of the dry weight of the algae. They consist mainly of rhamnose, glucuronic acid, glucose, galactose and xylose and also include sulfate groups. They may also include varying amounts of galacturonic acid, iduronic acid and mannose. Rhamnose is generally sulphated at position 3. Xylose may also be partially sulphated. Most of the constituent sugars are distributed according to repetitive sequences. The two major ones are disaccharide sequences, one so-called type A (A3s) 3-sulphoxide ulvanobiuronic acid comprising 3-sulphate rhamnose linked to glucuronic acid by a 1-4 type bond, the other 3021535 6 called ulvanobiuronic acid with 3 type B sulfates (B3s) comprising rhamnose 3-sulfate bound to Iduronic acid by a linkage of type 1-> 4. The relative proportion of sugars varies according to the place of harvest of the ulva, the species and also the time of harvest in the year.
    [0010] To obtain ulvans by extraction from ulva, reference can be made to the extraction methods described in Carbohydrate Research 274 (1995) pages 251-261 or Hydrobiologia 326/327; pp. 473-480 (1996). In general, the extracts used according to the invention are advantageously prepared by extraction in aqueous medium of ulva and / or enteromorphs, the extraction step being advantageously followed by an ultrafiltration step. Extraction of ulvans can be carried out either from dried seaweed or preferably from fresh seaweed frozen at -30 ° C. More specifically, the algae are thawed and then crushed roughly into pieces of about 0.5 cm and macerated in 0.05 M sodium oxalate for 2 hours, with constant stirring, at 85-90 ° C. The suspension is then filtered on canvas and then on Buchner, after addition of 2% of filtering ground (Celatom® Diatomite, Eagle-Picher). The filtrate is then concentrated by ultrafiltration (10 kDa membrane, Millipore) and diafiltered against 5 volumes of ultrapure water. After freezing, the extract is lyophilized and kept dry.
    [0011] According to one particular aspect of the invention, the sulphated polysaccharide of ulvan type is preferably composed of 2 to 60% by weight of rhamnose, preferably 20 to 30% of rhamnose, preferably about 25% of rhamnose, relative to the total weight of the polymer. Preferably, the sulphated polysaccharide of ulvan type contains from 5 to 25% of sulphates (SO4), and preferably from 10% to 20%, relative to the total weight of the polymer, expressed as a percentage of dry matter. According to a preferred aspect of the invention, the ulvanated sulphated polysaccharide is composed of approximately 25.30% of rhamnose, 17.40% of glucuronic acid, 3.20% of iduronic acid, 3.4% of xylose, 1.80% galactose, 0.70% glucose and 15.70% sulfate, expressed as a percentage of dry matter, the remainder being mineral matter and proteins. This ulvan has two populations of a molecular weight of about 1,060,000 (54%) and about 120,000 Da (46%).
    [0012] According to another aspect of the invention, the ulna-type sulphated polysaccharide is composed of about 22.20% of rhamnose, 1.70% of glucuronic acid, 6.50% of iduronic acid, 7.6. xylose%, 1.2% galactose, 3.2% glucose, 0.10% mannose and 14% sulfate, expressed as a percentage of dry matter, the remainder being mineral matter and proteins. This ulvan has two populations with a molecular weight of about 580,000 Da (37%) and about 40,000 Da (63%). This ulvane can in particular be extracted from the species ulva armoricana. According to yet another aspect of the invention, the ulna-type sulphated polysaccharide is composed of about 29.70% of rhamnose, 11.50% of glucuronic acid, 11.30% of 10% of iduronic acid, 4.10%. xylose%, 1.20% galactose, 2.70% glucose and 12.98% sulfate, expressed as a percentage of dry matter, the remainder being mineral matter and proteins. This ulvan has a molecular weight of about 875,000 Da. This ulvane can in particular be extracted from the species enteromorpha intestinalis. Particularly suitable for the invention, the extract Ulvane UR, obtained from the alga Ulva rotundata according to the protocol described above and having the following characteristics (in percentages by weight): dry matter (% MB) = 94.9 % Organic Matter (% MS) = 75.9% Mineral Matter (% MS) = 24.1% 20 Na (% MS) = 5.74% Proteins (N x 6.25) (% MS) = 7.40 % Rhamnose% = 25.30% Glucuronic acid = 17.40% Iduronic acid% = 3.20% Xylose% = 3.4% Galactose% = 1.80% Glucose% = 0.70% Sulphate content = 15 , 70% the residue being mineral material including 5.74% Na.
    [0013] These contents were characterized according to the dosing methods referenced in document FR 2 982 152.
    [0014] As representative of ulvan suitable for the invention, may be mentioned ulvan UR709018 / IN07-535 of CEVA. Cosmetic Compositions According to a particular aspect of the invention, the sulphated polysaccharide of the ulvan type is used in a cosmetic composition. Those skilled in the art can easily, on the basis of their general knowledge, determine the effective amounts as a tensor for a sulphated ulvarated polysaccharide. According to one particular embodiment of the invention, the sulphated polysaccharide of the ulvan type may be present in the cosmetic composition at a concentration of between 0.01% and 3% by weight, preferably from 0.1% to 2% by weight. more preferably is present in an amount of about 0.5% to 1.5% by weight, based on the total weight of the composition. As can be seen from the examples below, a 1% polysaccharide formulation applied at 10 mg (formulation) / cm 2 of skin is sufficient to achieve an effective tensor effect. The cosmetic compositions according to the invention may be in any galenical form normally used in cosmetics. Thus, they may be in the form of aqueous, hydroalcoholic or oily solutions, dispersions of the lotion or serum type, anhydrous or oily gels, emulsions of liquid or semi-liquid consistency of the milk type, obtained by dispersion. a fatty phase in an aqueous phase (O / W) or conversely (W / O), suspensions or emulsions of soft, semi-solid or solid consistency of the cream, gel, microemulsion or microcapsule type; , microparticles, or vesicular dispersions of ionic and / or nonionic type. These compositions are prepared according to the usual methods. The compositions used according to the invention may be more or less fluid and have the appearance of a white or colored cream, an ointment, a milk, a lotion, a serum or a paste. or foam. They may optionally be applied to the skin in aerosol form. They may also be in solid form, for example in the form of a stick.
    [0015] A composition according to the invention may advantageously be in the form of an aqueous lotion, an aqueous gel or an emulsion, especially oil in water or water in oil. In the case of an emulsion, the proportion of the fatty phase can then vary from 5 to 80% by weight, and preferably from 5 to 50% by weight relative to the total weight of the composition. This fatty phase may comprise oils, gums, and / or waxes usually used in the field of application under consideration. The emulsions suitable for the invention may also comprise at least one emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture. Advantageously, the emulsifiers are appropriately chosen according to the emulsion to be obtained (W / O or O / W). The emulsifiers are generally present in the composition in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20% by weight, relative to the total weight of the composition.
    [0016] The compositions according to the invention may also comprise any conventional adjuvant, in usual proportion, which does not adversely affect the desired properties, in particular the tensor effect of the compositions. As adjuvant conventionally used in the cosmetics field, mention may be made of hydrophilic or lipophilic gelling agents, thickeners, preservatives, antioxidants, solvents, perfumes, fillers, filters, pigments, odor absorbers, pH agents and dyestuffs. The amounts of these various adjuvants are those conventionally used in the field under consideration, and for example from 0.01 to 20% of the total weight of the composition.
    [0017] According to another aspect of the invention, the cosmetic composition comprises, in addition to at least one sulphated polysaccharide of the ulvan type, other anti-aging active agents chosen from desquamating agents, moisturizing agents, agents stimulating the proliferation and / or differentiation of keratinocytes, agents stimulating the synthesis of collagen and / or elastin or preventing their degradation, depigmenting agents, anti-glycation agents, agents stimulating the synthesis of glycosaminoglycans, dermo-decontracting agents or muscle relaxants anti-oxidant and anti-radical agents, and mixtures thereof.
    [0018] The invention also relates to a cosmetic treatment method intended to provide a tightening effect and / or of reading of the skin, in particular of the face and in particular to reduce and / or erase and / or smooth the wrinkles and fine lines. skin, and bags under the eyes, characterized in that it comprises the application to the skin of a cosmetic composition comprising at least one ulna-type sulphated polysaccharide, in particular an extracted ulvanated sulphated polysaccharide, or used in the form of an extract, ulvae or enteromorphs. In particular, said ulna-type sulphated polysaccharide, in particular an ulvanated sulphated polysaccharide extracted or used in the form of an extract, of at least one of the following species: Ulva lactuca, Ulva rigida, Ulva armoricana , Ulva rotundata, Ulva obscura, Enteromorpha compressa, Enteromorpha intestinalis and Enteromorpha ramulosa, and combinations thereof, and preferably of the species Ulva rotundata. The process of the invention is more especially adapted for an application on the face, in particular the skin of the eye contour and in particular the bags under the eyes, the neck and the décolleté. The application of the composition according to the invention is carried out according to the usual techniques, for example by application (in particular of creams, gels, serums, lotions) on the skin to be treated. As part of this process, the composition may be, for example, a care composition or a make-up composition, especially a foundation. The invention is illustrated in more detail in the following examples. These examples serve to illustrate the invention without, however, being limiting in nature. EXAMPLE 1 Cosmetic Composition An anti-wrinkle serum having the following composition was prepared: Ulvan UR709018 / IN07-535 from CEVA. (sulphated polysaccharide from Ulva rotundata) lg MA - Preservatives 0.85 g - Water qs 100 g The serum thus obtained is applied to the face; it can effectively smooth out fine lines and wrinkles, and reduce the roughness of the skin.
    [0019] EXAMPLE 2 Evaluation of the tensor effect of the serum of Example 1 The following test makes it possible to demonstrate the microrelief smoothing of a stratum corneum leaf (SC). On face skin in vivo this smoothing will result in decreased visibility of fine lines and small skin surface imperfections. Specifically, its protocol is as follows: An insulated SC sheet is attached to a microscope slide with a double-sided adhesive tape so that the SC is attached to the edges but remains "suspended" in the middle, so that avoid the influence of an underlying substrate on the 10 evolutions of relief. The SC must be deposited without tension, to preserve the natural relief of the surface of SC. The SC is pre-conditioned at 75% relative humidity and measurements are made before and after treatment, possibly with kinetic monitoring, in a glove box always at 75% relative humidity. The characterization of microtopography in 3D is performed by optical profilometry (Optical Profiler NT9100, Brucker), with a micrometric resolution in x, y and z. Microphotography acquisitions on 5x5 mm areas are made before treatment (TO). Then, the tensor polymer solution listed is deposited in an amount of 1.1 L / cm 2 and spread on the SC surface with the micropipette. The acquisition of microtopography is repeated 1h30 and 18h after the deposition of the tensor solution (T1h30 20 and T18h) The quantitative analysis is made by calculating many parameters: roughness, average amplitude, symmetry of heights with respect to the average plane, slope medium, developed surface, curvature of peaks, depth of valleys, etc. Spatial filtering (e.g., using Fourier transform) is necessary to separate the different contributions of x-y elements. In the context of the cutaneous topography, the data according to the spatial wavelengths (X) are separated and only the "shape", corresponding to the wavelengths> 50 i.tm, is retained. This selectively reflects the overall topography of the skin (trays, furrows, fine lines ...). This parameter is well suited for filler and tensor studies. Since the SC samples are fixed around the application zone, the tensor effect (reduction of the additional surface area brought by the texture relative to a flat surface) is reflected in surface smoothing and thus in reduction of the roughness. Overall 3021535 12. The roughness of a surface Z - (the height Z as a function of position x, y for all points / pixels of the surface) is defined according to the following equation: Rq = The results of the profilometric test are presented below as the relative difference in roughness Rq before (TO) and after (T1h30 or T18h) the treatment of SC: 1 {10e ... / 0 The reproduction of this test with the serum of Example 1 makes it possible to obtain the 10 Table 1. The data set was established at the macroscopic scale, X> 50 μm. The more negative values correspond to a more efficient smoothing. Table 1 Treatment Roughness variation Rq A 1h30 Roughness variation Rq A 18h Ulvane 1% - 48% - 22.3 Vehicle only - 10% +28.4 15 These data show that the polysaccharide according to the invention has a strong effect of immediate microrelief smoothing . A significant decrease in the roughness of SC is indeed observed at 1:30 after treatment, or immediately after drying of the polysaccharide film. The contraction of polymer during drying results in surface smoothing.
    [0020] It has also been found that the reduction in roughness remains significant 18 hours after treatment with Ulvane, in the absence of mechanical stress. In conclusion, the surface smoothing effect obtained by the application of a composition with "Ulvane" is therefore residual and remains important at 18h. 25
    权利要求:
    Claims (10)
    [0001]
    REVENDICATIONS1. Cosmetic use of an ulna-type sulphated polysaccharide as a tensor and / or skin smoothing agent
    [0002]
    2. Use according to claim 1 for reducing and / or erasing and / or smoothing wrinkles and fine lines of the skin and bags under the eyes.
    [0003]
    3. Use according to claim 1 or 2 for reducing the cutaneous microrelief of the skin.
    [0004]
    4. Use according to claim 1, 2 or 3 for reducing the roughness of the skin.
    [0005]
    5. Cosmetic use according to one of claims 1 to 4, characterized in that the sulphated polysaccharide ulvan type is composed of 2 to 60% by weight of rhamnose, preferably 20 to 30%, preferably about 25%, relative to the total weight of the polysaccharide. 15
    [0006]
    6. Cosmetic use according to one of claims 1 to 5, characterized in that the sulphated polysaccharide ulvan type is extracted or used in the form of an extract ulva or enteromorphs.
    [0007]
    7. Cosmetic use according to claim 6, characterized in that the sulphated polysaccharide of ulvan type is extracted or used in the form of an extract of at least one of the following species: Ulva lactuca, Ulva rigida, Ulva armoricana, Ulva rotundata, Ulva obscura, Enteromorpha compressa, Enteromorpha intestinalis and Enteromorpha ramulosa, and combinations thereof, and preferably of the species Ulva rotundata.
    [0008]
    8. Cosmetic use according to one of claims 1 to 7, characterized in that the sulphated polysaccharide of ulvan type is used in a cosmetic composition, especially a composition in the form of an oil-in-water emulsion, a water-in-oil emulsion or an aqueous gel.
    [0009]
    9. Cosmetic use according to claim 8, characterized in that the sulphated polysaccharide of ulvan type is present at a concentration of 0.01 to 3% by weight in the cosmetic composition, relative to the total weight of the composition.
    [0010]
    10. Cosmetic treatment process intended to provide a tensing effect and / or smoothing of the skin and in particular to reduce and / or erase and / or smooth wrinkles, skin wrinkles and under-eye bags, characterized in that it comprises the application on the skin of a cosmetic composition comprising at least one sulphated polysaccharide of ulvan type as defined in claims 6 to 7.
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    同族专利:
    公开号 | 公开日
    FR3021535B1|2016-06-10|
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    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
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    FR3057770A1|2016-10-21|2018-04-27|Seprosys|USE OF A ULVE EXTRACT AS ANTI-AGE COSMETIC AGENT|
    FR3084590B1|2018-07-31|2021-01-08|Lvmh Rech|COSMETIC EMULSION PRODUCT INCLUDING FUNCTIONALIZED SILICONES|
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    FR3084589B1|2018-07-31|2021-01-08|Lvmh Rech|COSMETIC PRODUCT INCLUDING FUNCTIONALIZED SILICONES AND A TENSIONING POLYMER|
    EP3870139A1|2018-11-27|2021-09-01|Colgate-Palmolive Company|Multi-benefit personal care compositions and methods for the same|
    FR3105924A1|2020-01-08|2021-07-09|Odycea|COSMETIC ACTIVE PRINCIPLE FROM ALGAE OF THE ULVOPHYCEAL CLASS REINFORCING THE BARRIER EFFECT, PLASTICITY, DEQUAMATION AND HOMEOSTASIS OF THE EPIDERMIS, COMPOSITION INCLUDING IT AND USE|
    法律状态:
    2015-05-08| PLFP| Fee payment|Year of fee payment: 2 |
    2015-12-04| PLSC| Search report ready|Effective date: 20151204 |
    2016-04-12| PLFP| Fee payment|Year of fee payment: 3 |
    2017-04-13| PLFP| Fee payment|Year of fee payment: 4 |
    2018-04-11| PLFP| Fee payment|Year of fee payment: 5 |
    2020-04-14| PLFP| Fee payment|Year of fee payment: 7 |
    2021-04-12| PLFP| Fee payment|Year of fee payment: 8 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1454794A|FR3021535B1|2014-05-27|2014-05-27|COSMETIC USE OF A SULFATE POLYSACCHARIDE|FR1454794A| FR3021535B1|2014-05-27|2014-05-27|COSMETIC USE OF A SULFATE POLYSACCHARIDE|
    PCT/IB2015/053978| WO2015181750A1|2014-05-27|2015-05-27|Cosmetic use of a sulphated polysaccharide|
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